Symbol
Name
ID

Dclre1c
DNA cross-link repair 1C
MGI:2441769

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Increased circulating IgE level

Decreased circulating IgG level

Decreased circulating antibody level

Panhypogammaglobulinemia

Eosinophilia

B lymphocytopenia

Severe B lymphocytopenia

Decreased proportion of CD3-positive T cells

Abnormally low T cell receptor excision circle level

Lymphopenia

Autoimmune thrombocytopenia

Recurrent aphthous stomatitis

Recurrent upper respiratory tract infections

Recurrent upper and lower respiratory tract infections

Lymph node hypoplasia

Lymphadenopathy

Generalized lymphadenopathy

Aplasia of the thymus

Hypoplasia of the thymus

Splenomegaly

Absent tonsils

Recurrent gastroenteritis

Otitis media

Chronic otitis media

Hashimoto thyroiditis

Erythroderma

Chronic oral candidiasis

Skin rash

Pneumonia

Autoimmunity

Immunodeficiency

Severe combined immunodeficiency

Sepsis

BCGitis

Recurrent opportunistic infections

Recurrent bacterial infections

Recurrent mycobacterial infections

Recurrent fungal infections

Recurrent respiratory infections

Recurrent bronchitis

Recurrent viral infections

Disease(s) Associated with DCLRE1C

common variable immunodeficiency

Omenn syndrome

severe combined immunodeficiency with sensitivity to ionizing radiation

Mouse Phenotypes

immune system phenotype

decreased B cell proliferation

decreased T cell proliferation

absent thymus cortex

decreased thymus weight

decreased thymocyte number

decreased DN1 thymic pro-T cell number

decreased DN4 thymocyte number

abnormal B cell differentiation

abnormal class switch recombination

absent immature B cells

abnormal immunoglobulin heavy chain V(D)J recombination

increased pro-B cell number

arrested B cell differentiation

abnormal T cell receptor V(D)J recombination

abnormal T cell receptor beta chain V(D)J recombination

decreased double-positive T cell number

arrested T cell differentiation

increased neutrophil cell number

decreased mature B cell number

decreased B-1 B cell number

decreased B cell number

absent B cells

decreased pre-B cell number

increased NK cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased central memory CD8 positive, alpha-beta T cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

decreased NK T cell number

decreased T cell number

absent T cells

decreased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

abnormal mononuclear cell morphology

small spleen

spleen hypoplasia

abnormal spleen B cell follicle morphology

decreased splenocyte number

abnormal leukocyte physiology

decreased IgM level

abnormal lymph node morphology

small lymph nodes

impaired humoral immune response

decreased response to antigen

Availability

Mouse Genotype

Dclre1c^m1Brck/Dclre1c^m1Brck

Dclre1c^m1Btlr/Dclre1c^m1Btlr

Dclre1c^M2Btlr/Dclre1c^M2Btlr

Dclre1c^m3Btlr/Dclre1c^m3Btlr

Dclre1c^tm1.1Fwa/Dclre1c^tm1.1Fwa

Dclre1c^tm1.1Jpdv/Dclre1c^tm1.1Jpdv

Dclre1c^tm1Fwa/Dclre1c^tm1Fwa

Dclre1c^tm1Jsek/Dclre1c^tm1Jsek

Dclre1c^tm2.2Jpdv/Dclre1c^tm2.2Jpdv

Dclre1c^tm2Mcow/Dclre1c^tm2Mcow

Dclre1c^tm2.1Jpdv/Dclre1c^tm2.2Jpdv
Tg(Cr2-cre)3Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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